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European Bioinformatics Institute -- Proteome Analysis Database, InterPro, CluSTr; Scanalytics -- DNA-Scan, Gene Profiler; Celera s Paracel -- GeneMatcher2.


The Swiss-Prot group at the European Bioinformatics Institute has compiled the Proteome Analysis Database to provide comparative analysis of predicted protein coding sequences of the complete genomes of bacteria, archaea, and eukaryotes.

A program has been written to carry out InterPro proteome comparisons for any of the proteomes contained in the database. EBI’s CluSTr (Clusters of Swiss-Prot +Trembl) database is used to classify Swiss-Prot and Trembl proteins into groups of related proteins.

The database is available online (

Scanalytics is now bundling its DNA-Scan program for the automated base calling of DNA sequencing gels with its Gene Profiler software for genotyping and DNA fingerprint analysis.

DNA-Scan uses artificial intelligence algorithms for automatic base calling of an entire sequencing gel in minutes, according to the company. Gene Profiler is able to make comparisons between gels and stores the information in a built-in database.

Celera’s Paracel unit has introduced GeneMatcher2, a high-throughput supercomputer for sequence similarity analysis.

GeneMatcher2 contains over 27,000 programmable parallel processors. Paracel said it can execute Smith-Waterman and hidden Markov model algorithms thousands of times faster than the latest generation microprocessor.

GeneMatcher2 builds upon Paracel’s GeneMatcher1 and GeneMatcher-Plus accelerators.

Filed under

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.