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European Bioinformatics Institute -- Proteome Analysis Database, InterPro, CluSTr; Scanalytics -- DNA-Scan, Gene Profiler; Celera s Paracel -- GeneMatcher2.

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The Swiss-Prot group at the European Bioinformatics Institute has compiled the Proteome Analysis Database to provide comparative analysis of predicted protein coding sequences of the complete genomes of bacteria, archaea, and eukaryotes.

A program has been written to carry out InterPro proteome comparisons for any of the proteomes contained in the database. EBI’s CluSTr (Clusters of Swiss-Prot +Trembl) database is used to classify Swiss-Prot and Trembl proteins into groups of related proteins.

The database is available online (www.ebi.ac.uk/proteome).

Scanalytics is now bundling its DNA-Scan program for the automated base calling of DNA sequencing gels with its Gene Profiler software for genotyping and DNA fingerprint analysis.

DNA-Scan uses artificial intelligence algorithms for automatic base calling of an entire sequencing gel in minutes, according to the company. Gene Profiler is able to make comparisons between gels and stores the information in a built-in database.

Celera’s Paracel unit has introduced GeneMatcher2, a high-throughput supercomputer for sequence similarity analysis.

GeneMatcher2 contains over 27,000 programmable parallel processors. Paracel said it can execute Smith-Waterman and hidden Markov model algorithms thousands of times faster than the latest generation microprocessor.

GeneMatcher2 builds upon Paracel’s GeneMatcher1 and GeneMatcher-Plus accelerators.

Filed under

The Scan

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Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.