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Entelos, Rosetta Biosoftware, GeneGo, Insilicos, Ingenuity, modENCODE, NRBSC

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J&JPRD Extends Entelos Collaboration for Five More Years

Entelos said this week that it has expanded its research collaboration with Johnson & Johnson Pharmaceutical Research & Development to include "multiple therapeutic areas" over a five-year term.

The companies began collaborating in 1999, and J&JPRD is currently using Entelos' models to validate targets, select biomarkers, and optimize clinical trials for type II diabetes, obesity, and anemia.

During the first year of this new agreement, Entelos said it will "dedicate several teams of research engineers and life scientists to support specific projects using its PhysioLab platforms on behalf of J&JPRD and its affiliates."

Additional details of the collaboration were not disclosed.


FoxHollow Technologies Licenses Rosetta Resolver for CVD Research

Rosetta Biosoftware said this week that FoxHollow Technologies has licensed its Resolver system for research on cardiovascular disease.

FoxHollow markets an atherosclerotic plaque excision device for treating peripheral arterial disease. The company will use Resolver to correlate genetic profiles of human atherosclerotic plaque samples with clinical findings in order to develop therapies targeted at atherosclerosis, Rosetta said.

FoxHollow will use the system to evaluate data generated in a large-scale pharmacogenomics collaboration with Rosetta parent company Merck.

The companies entered the collaboration last September.


Berlex Licenses GeneGo's MetaCore

GeneGo has licensed its MetaCore pathway informatics platform to Berlex, a US affiliate of Schering, GeneGo said this week.

The license provides researchers at Berlex and Schering with access to MetaCore for analyzing gene expression, proteomic, metabolic, and other data in multiple therapeutic areas, including oncology.

Financial terms of the agreement were not provided.


Insilicos Awarded $400K to Study Heart Disease

Proteomics software startup Insilicos said this week that it has received a two-year $400,000 grant from the National Heart, Lung, and Blood Institute to develop a blood test for heart disease.

Insilicos will use its proprietary computational methods to analyze blood samples in order to develop the diagnostic.


PNDRC to Use Ingenuity Pathway Analysis

The Pritzker Neuropsychiatric Disorders Research Consortium has licensed Ingenuity Pathways Analysis, Ingenuity Systems said this week.

PNDRC will use the system to study gene expression in the context of neuronal pathways, circuits, and target systems.


NIH to Award $4.5M for modENCODE Data-Coordination Center

The National Institutes of Health has issued a request for applications titled "A Data Coordination Center for the Model Organism ENCODE Project," which solicits applications to implement a data coordination center for modENCODE, the ENCODE (Encyclopedia of DNA Elements) project for model organisms.

NIH said it will award $1.5 million per year for three years to a single center.

The modENCODE project will conduct experiments to "identify all of the sequence-based functional elements in the Caenorhabditis elegans and/or Drosophila melanogaster genomes," NIH said in the RFA.

The data-coordination center will be funded "to develop, house, and maintain databases to track, store, and provide access to the data generated as part of the modENCODE Project. In addition, the DCC will import data from related projects that are relevant to the goals of the modENCODE Project," the RFA said.

Letters of intent from interested organizations are due June 21 and applications are due July 21.

The complete RFA is available at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-06-007.html.


NRBSC to Host Biosimulation Workshop

The National Resource for Biomedical Supercomputing at the Pittsburgh Supercomputing Center will host a workshop entitled "Computational Methods for Spatially Realistic Microphysiological Simulations" June 6-9.

The workshop will cover the design and simulation of models "focused on diffusion-reaction systems such as neurotransmission and biochemical networks," according to a statement from NRBSC.

Instructors will introduce new versions of the MCell and DReAMM software packages, and will highlight new Monte Carlo methods for 3D simulation of reactions in solution and on biological surfaces.

The application deadline is April 26. Further details are available at http://www.nrbsc.org/education/workshops/cmms/.

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Rare Heart Inflammation Warning

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Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.