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Eli Lilly, Entelos, US Department of Justice, Invitrogen, Brendan Technologies, CLC Bio, GeneGo, Yale Microarray Center, Johns Hopkins University, Caringo, LabVantage

Eli Lilly Takes Perpetual License to Entelos’ DrugMatrix Database
Entelos said this week that Eli Lilly has purchased a perpetual license to its DrugMatrix toxicogenomics database.
Under the terms of the agreement, Lilly will make a one-time payment to Entelos for a perpetual license to the database and customized report services from the company’s ToxFx business, with the option for continued support. No financial terms were disclosed.
Entelos, a biosimulation firm that develops models to help predict drug response, picked up the DrugMatrix database in its acquisition of Iconix last August [BioInform 09-07-08]. 
The database is a reference set of gene expression profiles for benchmark drugs and compounds that are linked to pharmacology, toxicology, and clinical pathology measurements. It currently includes profiles from more than 630 different compounds.

US Department of Justice Licenses Bloodhound
Cambridge, Mass.-based bioinformatics company Ananomouse said this week that the US Department of Justice has purchased a worldwide unlimited license to its Bloodhound software to support the Federal Bureau of Investigation’s forensic genomics program, the Combined DNA Index System, or CODIS.
The license incorporates an endowment of the underlying Bloodhoud intellectual property in perpetuity for humanitarian purposes.
Ananomouse said that Bloodhound is an “enterprise-grade kinship analysis identification technology” that will support the CODIS program’s mission to identify missing persons or disaster victims. 
In a statement, Thomas Callaghan, chief of the FBI Laboratory’s CODIS unit, said that Ananomouse’s technology is a “valuable asset to our efforts” in forensics and law enforcement. 
Bloodhound analyzes short tandem repeats and is based on an architecture designed for distributed processing. It is built on client-server technology in order to access a centralized database over a network.

Invitrogen Integrates Brendan Technologies' Softward with Protein Analysis Tools
Invitrogen said this week that it has signed an exclusive agreement with software developer Brendan Technologies to integrate the company’s StatLIA assay analysis software with its protein analysis tools. The companies did not disclose the agreement’s financial terms.
Invitrogen said that the StatLIA software will be designed to work with protein quantitation via mass spectrometry, a technology platform that the company will add to its offerings when its acquisition of Applied Biosystems closes in the fall.
"This software maximizes the value of our reagents through state-of-the-art computations and analysis of proteomics mass spectrometry," said Kip Miller, Invitrogen's senior vice president of BioDiscovery, in a statement. 

CLC Bio Selects New Headquarters
Danish bioinformatics firm CLC Bio said it has a new building for its headquarters in the Katrinebjerg neighborhood of Aarhus, Denmark.
The company had “outgrown” its previous location at the Aarhus Science Park, Thomas Knudsen, CEO of CLC Bio, said in a statement. 
Founded in January 2005, the company now has nearly 50 employees, with offices in Aarhus; Boston; Nottingham, UK; Rio de Janeiro, Brazil; and New Delhi and Hyderabad, India.
The company said it is opening another new office in Asia later this year, but did not provide further details.

GeneGo Certifies Yale Microarray Center as 'Center of Excellence,' Extends Unilever License
GeneGo said this week that it has certified Yale University’s Keck Microarray Center as a “Center of Excellence” and that it will be a GeneGo training facility and provide access and support for its software tools.
Under the terms of the agreement, Yale researchers will have access to GeneGo's MetaCore software, as well as training and advanced support.
Yale researchers will use MetaCore for basic and translational research; cancer biology; neuroscience research; and other clinical conditions, GeneGo said in a statement. 
Separately, GeneGo said that consumer goods firm Unilever has extended its license to MetaCore for use in safety studies.

Johns Hopkins to Use Caringo Software for Genotyping Data Storage
Austin, Texas-based Caringo said this week that Johns Hopkins University’s Center for Inherited Disease Research will use its CAStor software for scalable archive storage of genotyping data.
The CIDR is a centralized facility that provides genotyping and statistical genetics services for investigators including those at 13 of the National Institutes of Health.
According to Caringo, the CIDR has implemented a 31-node CAStor cluster with 104 TB of available capacity and 82 TB in use.

Harvard Medical School/Brigham and Women’s Hospital Picks LabVantage’s Sapphire for Legacy LIMS Phaseout
LabVantage Solutions said this week that the Channing Laboratory at Brigham and Women's Hospital and Harvard Medical School has licensed its Sapphire BioBanking Solution.
The multidisciplinary lab is focused on the investigation of bacteriology, chronic disease epidemiology, and virology.
The Channing Lab will deploy Sapphire in its Respiratory Epidemiology Genotyping Laboratory as part of a multi-phase project to replace “significant portions” of its existing laboratory information management systems and other internally developed software packages, LabVantage said.
LabVantage said that the lab has developed and maintained its own in-house solutions for genotyping research and associated laboratory information management and has now chosen to switch to a commercial product for its biorepository and sample-tracking system.
"We were primarily seeking a solution for our biorepository needs, but quickly found that many of our internally built laboratory systems and process would be tied to the biorepository processes," Scott Weiss, principal investigator for the Channing Laboratory, said in a statement. "We needed a solution that would provide state-of-the-art biorepository management and that would also replace our legacy systems with standardized solutions.”

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The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.