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Downloads & Upgrades: Mar 19, 2010

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CLC Bio has released a whole-genome de novo assembler that it said will assemble genomes "of any size," including human and plant genomes, on a single workstation.

The company said that the assembler also offers a graphical user interface that allows molecular biologists to easily set up, adjust, and run their large genome de novo assemblies.

Compared to other de novo assembly software, which CLC said requires more than 300 GB of RAM for large genome assemblies, the company's assembler "can assemble the same datasets on a single workstation computer with only 48 GB of RAM."

The company said that the assembler is also up to 50 times faster than existing packages and that it can mix datasets from different sequencing technologies, including Illumina, SOLiD, Roche 454, Helicos, and Sanger sequencing instruments.


Release 103 of the EMBL Nucleotide Sequence Database is available from the European Bioinformatics Institute FTP site as well as the US mirror site and other mirrors.

The release contains more than 185 billion sequence entries comprising 281 trillion nucleotides. Files total 133 GB compressed and 963 GB uncompressed.


Accelrys has launched Discovery Studio 2.5.5, which includes new protein-modeling algorithms, access to the latest version of the Cambridge Crystallographic Data Center's GOLD docking program, and improved usability and performance.

The release includes a new 3D quantitative structure-activity relationship method, a protocol for calculating residue electrostatic energy for predicting protein stability and thermostability, two new user interface "discovery guides," and 64-bit server compatibility.


Version 32 of the Reactome Knowledgebase is available here.

The latest version of the curated resources includes a new topic on the role of the CDO cell-surface protein in myogenesis, as well as several revised and updated topics.


RefSeq 40 is available via FTP here.

Release 40 includes 13,853,798 records, 9,856,489 proteins, and sequences from 10,291 different organisms.

The Scan

UK Funds to Stay Ahead of Variants

The UK has announced a further £29.3 million to stay on top of SARS-CoV-2 variants, the Guardian reports.

Push for Access

In a letter, researchers in India seek easier access to COVID-19 data, Science reports.

Not as Cold

Late-stage trial results are expected soon for an RNA-based vaccine that could help meet global demand as it does not require very cold storage, the New York Times writes.

Genome Research Papers on Microbes' Effects on Host Transfer RNA, Honeybee Evolution, Single-Cell Histones

In Genome Research this week: influence of microbes on transfer RNA patterns, evolutionary relationships of honeybees, and more.