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Downloads and Upgrades: UCSC Genome Browser, SMRT Analysis 1.4, 1-Click, and More


The University of California, Santa Cruz's genome browser group has released a new browser for the white rhinoceros Ceratotherium simum.

Bulk downloads of the sequence and annotation data are available here and here.

Pacific Biosciences said this week that it has updated its single molecule, real-time analysis software.

SMRT Analysis 1.4 includes a new hierarchical de novo genome assembly process that lets researchers assemble entire microbial and fungal genomes using PacBio long reads alone; a new multi-read consensus algorithm called Quiver; support for barcoded sample analysis; and improvements to tools for analyzing and visualizing bacterial methylomes.

Mcule has released 1-Click, a free online molecular docking solution for users looking to determine ligands' binding modes or docking scores.

The University of California, San Francisco, has released Chimera 1.7.

This version of the tool includes faster loading and graphics, improvements in lighting and interactive shadows, an interface to Modeller for building
missing loops, enhanced commands for animation, and other new features.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.