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Downloads and Upgrades: Simcyp Simulator 13, rtgSingleton and rtgPopulation beta, and more


Certara has released version 13 of the Simcyp Simulator, its software for quantitative prediction of drug-drug-interactions and pharmacokinetic-pharmacodynamic outcomes in virtual populations.

The release includes a physiologically-based pharmacokinetic model for monoclonal antibodies and therapeutic proteins, and a non-linear plasma protein and red blood cell binding facility among other features.

Real Time Genomics released its rtgSingleton product for analyzing individual genomic samples, and a beta version of its rtgPopulation product for case-control and cohort applications.

The singleton product is designed to analyze panels, exomes, or genomes on a case-by-case basis while the population product is designed for analyzing large numbers of samples.

The human genome annotation release 105 is now available from the National Center for Biotechnology Information.

Annotated genomic, transcript, and protein records are available through the integrated Entrez system and may be downloaded via ftp or the Aspera protocol.

OpenEye Scientific Software has released QUACPAC 1.6

This release incorporates several improvements as well as bug fixes.

Simulations Plus has released GastroPlus 8.5, the latest version of its pharmacokinetic and pharmacodynamic simulation software.

The release includes a new mechanistic precipitation model and a new method for transporter-based in vitro-in vivo extrapolation among other updates.

BioJava Legacy 1.8.4 is available here as well as from the BioJava maven repository.

Features in this release include minor improvements to the sequencing module as well as build fixes.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.