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Downloads and Upgrades: Simcyp Simulator 13, rtgSingleton and rtgPopulation beta, and more

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Certara has released version 13 of the Simcyp Simulator, its software for quantitative prediction of drug-drug-interactions and pharmacokinetic-pharmacodynamic outcomes in virtual populations.

The release includes a physiologically-based pharmacokinetic model for monoclonal antibodies and therapeutic proteins, and a non-linear plasma protein and red blood cell binding facility among other features.


Real Time Genomics released its rtgSingleton product for analyzing individual genomic samples, and a beta version of its rtgPopulation product for case-control and cohort applications.

The singleton product is designed to analyze panels, exomes, or genomes on a case-by-case basis while the population product is designed for analyzing large numbers of samples.


The human genome annotation release 105 is now available from the National Center for Biotechnology Information.

Annotated genomic, transcript, and protein records are available through the integrated Entrez system and may be downloaded via ftp or the Aspera protocol.


OpenEye Scientific Software has released QUACPAC 1.6

This release incorporates several improvements as well as bug fixes.


Simulations Plus has released GastroPlus 8.5, the latest version of its pharmacokinetic and pharmacodynamic simulation software.

The release includes a new mechanistic precipitation model and a new method for transporter-based in vitro-in vivo extrapolation among other updates.


BioJava Legacy 1.8.4 is available here as well as from the BioJava maven repository.

Features in this release include minor improvements to the sequencing module as well as build fixes.


The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.