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Downloads and Upgrades: Schrodinger Life Sciences 2013-2; BiNGO 3.0.1; and NextGene

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Schrödinger Life Sciences 2013-2 is now available.

This release features improvements to the company's Small-molecule Drug Discovery suite, which provides tools for lead discovery and optimization; its Biologics suite, which offers tools for modeling biologics, antibodies, and proteins; and its Materials Science suite, which offers tools for computing the structure, reactivity, and properties of chemical systems.


An updated version of BiNGO 3.0.1 is now available from the Cytoscape app store.

This updated version of the tool resolves issues that caused the app not to install properly. This version of BiNGO is compatible with Cytoscape 3.0.0 and higher.


SoftGenetics has added a copy number variation detection tool to its NextGene software.

With the CNV detection tool, which is available in NextGene 2.3.4, calls are made on the basis of changes in coverage, utilizing automatic measurement of noise and a novel Hidden Markov Model.


The National Center for Biotechnology Information has released Sequence Viewer 2.27.

Features in this release include new tiling path and contig tracks for assembled records, an interface to VDB cSRA graphs storage, and several bug fixes.

NCBI also released an updated version of dbSNP build 138.

This update includes data for mouse, Arabidopsis thaliana, honeybee, Caenorhabditis elegans, and rice. Overall, it provides more than 505 million submissions and 226 million reference variants for 131 species.


The genome browser group at the University of California, Santa Cruz has released three tracks that describe human genetic variation. These tracks are based on data in the Leiden Open Variation Database, the public version of the Human Gene Mutation Database, and the UniProt database.

The Scan

Looking for Omicron

NPR reports that SARS-CoV-2 testing in the US has gotten better but also that some experts say more needs to be done to better track the Omicron variant.

Holmes Alleges Abuse

The Associated Press reports that Theranos' Elizabeth Holmes has testified at her wire fraud trial that her business and romantic partner abused her.

Bit More Diverse, But More to Do

While Black and Hispanic patients are more likely to participate in cancer clinical trials than previously, they are still underrepresented, according to US News & World Report.

PNAS Papers on Yeast Gene Silencing, Zika Virus Inhibition, Immunoglobulin Hypermutation

In PNAS this week: gene silencing in Saccharomyces cerevisiae, possible neuroprotective role for SHFL in a mouse model of Zika virus infection, and more.