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Downloads and Upgrades: Reactome 44 and ACD/Spectrus DB

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Reactome 44 is available here.

Topics with new or revised information include immune system, cell cycle, extracellular matrix organization, metabolism, signal transduction, transmembrane transport of small molecules, and disease. New pathway illustrations include apoptosis extrinsic pathway, and trafficking and processing of endosomal toll-like receptors.


Advanced Chemistry Development, a cheminformatics software developer, has launched ACD/Spectrus DB, the database at the core of its Spectrus integrated analytical and chemical knowledge management platform.

According to its developers, ACD/Spectrus DB gathers information from multiple analytical instruments and connects chemical structures, reactions, schema, related analytical data, and chemical information, among other features. Users can make customizations to their systems such as automated processing, interpretation, sample tracking, and visualization.


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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.