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Downloads and Upgrades: MassHunter Profinder; GenBank 199.0, and Ensembl Genomes 21

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Agilent Technologies has released MassHunter Profinder, new software that’s designed for batch processing of complex mass spectrometric data.

According to the developers, MassHunter Profinder uses proprietary algorithms that are specially designed to identify differential compounds in highly complex data sets. It significantly reduces the noise associated with data profiling by employing a new recursive feature extraction workflow, which eliminates additional manual editing tasks such as stacking, adding, and deleting peaks. It also includes user-defined peak re-integration capabilities to help users identify fewer false-positives/negatives in their results.


GenBank Release 199.0 is now available via FTP from the National Center for Biotechnology Information.

Uncompressed flatfiles in this release require roughly 618 gigabytes for sequence files only. The ASN.1 data require approximately 508 GB.

The NCBI's rat genome annotation has also been updated to release 104.


Release 21 of Ensembl Genomes is available here.

This release includes updates to Ensembl Bacteria, Ensembl Fungi, Ensembl Metazoa, Ensmbly, Plants, and Ensembl Protists.


The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.