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Downloads and Upgrades: Human CCDS 15 and NEBioCalculator


The National Center for Biotechnology has released a Consensus Coding Sequence update for Homo sapiens annotation release 105. The update is available on the CCDS website and via FTP.

The release adds 349 new CCDS IDs to the human CCDS dataset and is based on comparative analysis of NCBI Homo sapiens annotation release 105 and Ensembl release 74. The human CCDS dataset now includes 29,045 proteins that correspond to 18,683 genes.

New England Biolabs has released NEBioCalculator, a collection of web-based calculators and converters that are useful in planning bench experiments in molecular biology laboratories.

The NEBioCalculator supports molarity calculation, OD260 conversion, ligation calculation, and mass/moles conversion for both dsDNA and ssRNA, and more. It provides calculations based on user-specified units. Scientists can input their measurements in milligram, microgram, nanogram or picogram amounts, leading to accurate calculations that require no further conversion.

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The Scan

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DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.