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Downloads and Upgrades: GenomeBrowse 2, Cascade, HomoloGene 68, and more

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Golden Helix has released GenomeBrowse 2, the latest version of its free genome browser for viewing sequence data. The release includes new features such as the ability to add custom genome reference sequences; integration with Evernote, which is a free app for organizing and sharing notes; as well as the ability to control the tool remotely.


The UCSC bioinformatics group said this week that it has added multiple genome segmentations tracks from the Encyclopedia of DNA Elements. These tracks display multivariate genome-segmentation performed on six human cell types, integrating ChIP-seq data for eight chromatin marks, RNA Polymerase II, the CTCF transcription factor, and input data.

The group also said that the browser's default displayed Transcription Factor ChIP-seq track will soon be moved to point to the latest data release.


The National Center for Biotechnology Information has released HomoloGene 68.

In this release, genome annotation was updated for 19 organisms, the number of HomoloGene groups increased to 44,233, and one organism, Xenopus tropicalis, was added. The release is available via ftp.


Dotmatics has released Cascade, a new solution that the company has developed for compound management and project tracking.

According to the company, Cascade includes tools to map laboratory workflows and business practices and lets users track samples and test results, among other features.


The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.