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Downloads and Upgrades: D360 7.0, MetaMiner Asthma, Knowledge Explorer 5.0, and Biobar 2.0.6


Certara has released D360 7.0, the latest version of its data query, analysis, and visualization solution.

New features in this release include all entity detail reports, which are used to assess compound status and to locate scientific data of interest to apply to current projects. The release also includes another feature that lets users add extra columns or rows of information to any dataset without re-running the entire query. Finally, users can also set up data searches to run automatically and regularly and access results in a variety of formats.

Thomson Reuters has launched MetaMiner Asthma, an industry-academic-government, disease-focused collaboration that aims to improve current understanding of pathological pathways that cause asthma and develop patient profiling methods to improve asthma diagnosis and treatment.

The company expects the MetaMiner Asthma program to generate more than 30 new pathway maps related to the signaling of immune cells involved in asthma pathology, such as T-cells, macrophages, eosinophils and neutrophils that will be delivered via the MetaCore platform. These maps and the insights from computational analyses using the pathways will be made available to participating members only for the first year, in order to aid in asthma research and protect intellectual property interests.

IO Informatics has launched Knowledge Explorer 5.0, the latest version of its semantic software for analyzing, visualizing, and managing data.

Version 5.0 offers improved visualization tools and performance on large datasets as well as enhancements to back-end connections.

The Protein Data Bank has released Biobar 2.0.6, the latest version of a Firefox toolbar that provides access to more than 45 biological data resources from within the browser.

Biobar lets users search and retrieve data from genomic, proteomic, functional, literature, taxonomic, structure, and plant- and animal-specific databases. They can also perform context menu searches for highlighted terms or keywords as well as access bioinformatics sites and services including those at the European Bioinformatics Institute, the National Center for Biotechnology Information, and the DNA Data Bank of Japan.

The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.