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Downloads and Upgrades: Blast+ 2.2.26; RefSeq 52; Ensembl Genomes 13; UCSC Genome Browser


The National Center for Biotechnology Information has released Blast+ 2.2.26

The release includes the Domain Enhanced Look-up Time Accelerated Blast, or DELTA-BLAST, application, which aligns protein query sequences to conserved domains in the Conserved Domains Database. It then performs a sequence database search using a position-specific score matrix derived from the aligned domains. It also includes new finite size correction, the last C toolkit binary release, and bug fixes among other updates.

RefSeq 52 is also available from the NCBI via FTP.

The release incorporates genomic, transcript, and protein data available as of March 5, and includes 20,235,247 records, 14,734,050 proteins, 2,908,495 RNAs, and sequences from 16,923 different organisms.

Ensembl Genomes 13 is available here.

This release includes a migration to version 66 of the Ensembl software and six new genomes, bringing the total genomes supported to 341. It also includes a new species for Ensembl Protists; the addition of Brassica rapa to Ensembl Plants; as well as synteny data for species in the Arabidopsis and Oryza genomes; and new oligo probe mapping from the GeneChip Maize Genome Array for Zea mays among other updates.

The genome bioinformatics group at the University of California, Santa Cruz, has released a new genome browser for the mouse genome assembly.

Filed under

The Scan

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With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.