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Downloads and Upgrades: BioDatomics; RefSeq 50; Mosaic; iCTNet; TACC

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This week, BioDatomics released a new version of its computational biology analysis and visualization platform.

According to the company, the combined software and hardware platform provides data storage and delivery capabilities and allows users to analyze, manipulate, visualize, and share data. It also includes a compression system that lets users move large volumes of data using a regular Internet connection.


RefSeq Release 50 is now available via FTP from the National Center for Biotechnology Information.

The full release incorporates genomic, transcript, and protein data available as of Nov. 7 and includes 18,815,153 records, 13,499,832 proteins, 2,751,095 RNAs, and sequences from 16,392 different organisms.


Two groups released new Cytoscape plugins this week.

A team at the Gladstone Institutes released a beta version of Mosaic, which is the first of a suite of Cytoscape applications that are being developed for annotating, analyzing, and visualizing networks with Gene Ontology terms. It partitions networks into subnetworks based on biological process terms; lays each one out using a cellular template based on cellular component terms; and then colors nodes based on molecular function terms.

Separately, a team in the University of California, San Francisco, neurology department released a plugin called the Integrated Complex Traits Networks, or iCTNet, which uses public information on gene expression, protein interaction, transcription factor binding sites, and drug targets to create multi-partite networks that can be used to study things like genetic similarities and differences across diseases, shared susceptibility pathways, and potential off-label use of FDA-approved drugs.


This week, the Texas Advanced Computing Center released an updated version of its computational biology software suite, which contains more than 30 new and updated applications for research in genomics, bioinformatics, and molecular simulation.


Filed under

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.