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Downloads and Upgrades: BioCyc Database, DiscoveryQuant 3.0, RefSeq 68, Cytoscape 3.2, and more

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SRI International has updated its BioCyc database collection to include a mobile application for remote access, as well as additional repositories that support researchers studying genomes and metabolic pathways. With these additions, version 18.5 of the resource adds access to 5,500 genomes and information about connections between sequences and biological function. It also links the sequences of microbial genomes to curated metabolic pathways among other updates.


AB Sciex has released DiscoveryQuant 3.0 software, a new version of its ADME solution for high-throughput drug discovery. The release speeds up the method development process using existing database information, automates on-column optimization, and easily analyzed and processes multiple samples at the same time among other capabilities


Cytoscape 3.2 is available here.

New features include faster startup, session loading, and drawing of large networks; the ability to display a node as a chart; and safer internal data handling of multi-threaded apps among others.


RefSeq 68 is now available from the National Center for Biotechnology Information via ftp.

The release has over 66 million records describing 46,968,574 proteins, 9,069,704 RNAs, and sequences from 49,312 distinct NCBI TaxIDs.


BioGazelle has released version 3.0 of its qbase+ qPCR data-analysis software. Features in this release include a data analysis wizard that simplifies the process of analyzing qPCR data. It provides step-by-step directions for importing data, annotating runs, doing data quality control, validating reference gene stability, performing normalization, and more.


MacVector has released MacVector 13.5, the latest version of its sequence analysis software. This release makes comparing large sequences faster and improves handling of NGS data. Specifically, it has a new interface and includes enhancements to the Align to Reference and Align to Folder functions among other updates.


Affymetrix has added a new feature to version 3 .0 of its Chromosome Analysis Suite software, a tool that enables researchers analyze and visualize the functional impact of copy number changes on gene expression in cancer samples. The company's newly added concurrent molecular analysis profiling capability lets cancer researchers combine whole-genome copy number data with gene expression profiles and explore the functional impact of copy number alterations.


The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.