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Downloads and Upgrades: Aperiomics' NGS Service, Chimera 1.10, and more


Aperiomics is rolling out three next-generation sequencing services based on its newly-minted Absolute-NGS pathogen detection platform. According to the company, its services will help customers identify and characterize known and unknown pathogens in a variety of samples including tissue, blood, plant, animal, or environmental. The company will launch the platform and services at Association for Molecular Pathology meeting in Washington DC later this month.

A new production release of UCSF Chimera 1.10 is available here.

Improvements in this version of the tool include updates to the structure analysis and modeling capabilities including protein contact maps color-coded by distance; and updates to the I/O display including new web fetch options, improved preferences for new molecules, and a new input format. Also included are new force field options in AmberTools 14, more choices for sequence alignment and conservation calculations in structure-derived amino acid substitution matrices, and more.

Additional details are provided in the release notes.

Tute Genomics said this week that it has added its genome annotation and interpretation platform to Illumina's BaseSpace apps store.

Tute's system provides tools for identifying and prioritizing functionally significant genetic variants. It annotates single nucleotide variants and insertions and deletions using information from more than 150 annotation sources including conservation scores, functional predictions, disease databases, and allele frequencies.

Rancho Biosciences said last week that it has made manually curated Cancer Genome Atlas datasets it created for several of its pharma and non-profit customers publicly available. These datasets are now available for other oncology groups.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.