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Downloads and Upgrades: Aperiomics' NGS Service, Chimera 1.10, and more


Aperiomics is rolling out three next-generation sequencing services based on its newly-minted Absolute-NGS pathogen detection platform. According to the company, its services will help customers identify and characterize known and unknown pathogens in a variety of samples including tissue, blood, plant, animal, or environmental. The company will launch the platform and services at Association for Molecular Pathology meeting in Washington DC later this month.

A new production release of UCSF Chimera 1.10 is available here.

Improvements in this version of the tool include updates to the structure analysis and modeling capabilities including protein contact maps color-coded by distance; and updates to the I/O display including new web fetch options, improved preferences for new molecules, and a new input format. Also included are new force field options in AmberTools 14, more choices for sequence alignment and conservation calculations in structure-derived amino acid substitution matrices, and more.

Additional details are provided in the release notes.

Tute Genomics said this week that it has added its genome annotation and interpretation platform to Illumina's BaseSpace apps store.

Tute's system provides tools for identifying and prioritizing functionally significant genetic variants. It annotates single nucleotide variants and insertions and deletions using information from more than 150 annotation sources including conservation scores, functional predictions, disease databases, and allele frequencies.

Rancho Biosciences said last week that it has made manually curated Cancer Genome Atlas datasets it created for several of its pharma and non-profit customers publicly available. These datasets are now available for other oncology groups.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.