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Downloads and Upgrades Aug 26, 2011


Decodon has released Delta2D 4.3

According to the developers, the latest release includes improvements in quality control and statistical tests, complete expression profiles for heterogeneous projects with its new Connector tool, and improved automatic warping among other features.

BioDiscovery has released Nexus Copy Number 6.0, the latest version of its software for DNA copy number analysis from CGH and single nucleotide polymorphism array data.

This version of the tool incorporates the Genomic Identification of Significant Targets in Cancer, GISTIC, algorithm for identifying regions of common genomic abnormalities and the Allele-Specific Copy Number Analysis of Tumors, ASCAT, algorithm which addresses sample aneuploidy and mosaicism, among other updates.

This week, Kinexus Bioinformatics launched the TranscriptoNET KnowledgeBase, an open access resource that provides human gene expression data from more than 300 types of human tissues and organs as well as more than 300 human cancer cell lines.

The tool includes information from the National Center for Biotechnology Information's Gene Expression Omnibus on mRNA expression levels for nearly 23,000 human genes to help users discover genes that are uniquely or commonly expressed in the human body, as well as interactions between proteins based on co-expression patterns.

Developers at the Joint BioEnergy Institute have made several changes to j5, the institute's automated DNA assembly software.

The software now features an improved graphical design canvas that improves its usability and accessibility. It is also better integrated with the JBEI sequence repository database platform and with liquid-handling robotics. For instance, it can design the arrangements of PCR reactions in 96-well plates across thermocycler gradients, JBEI said.

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.