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Downloads and Upgrades : Aug 19, 2011

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The National Center for Biotechnology Information has launched dbSNP build 134 for the human genome.

The complete data for build 134 can be found here in multiple formats.

The complete build summary for 134 is available here.

The release includes submissions from the 1000 Genomes Project interim phase I release and the National Heart, Lung, and Blood Institute Exome Sequencing Project. It adds 6,038,585 SNPs from 18 new organisms and an overall total of 108,182,122 new SNPs representing a total of 86 organisms.

The release includes new attributes that allow searching and filtering of human variation by clinical significance, allele origin, minor allele frequency, and suspected false SNPs.


NCBI has also released GenBank 185.0 via ftp.

Uncompressed 185.0 flatfiles require roughly 511 gigabytes for sequence files only or 550 gigabytes to include the short directory, index, and text files. The ASN.1 data require approximately 420 gigabytes.


The Protein Data Bank in Europe has released two modules for its PDBeMotif service, a program that’s used to analyze PDB entries in terms of structure, sequence, and chemistry. These tools provide users with information and statistics about ligands in PDB.

The first module retrieves residues with which a given ligand in the database interacts based on current PDB entries and plots the results on an interactive graph. The graph can be used to further view the PDB entries in which the interactions occur, or to do additional analyses using PDBeMotif.

The second tool lets users search for ligands in the database that interact with a
given set of residues and displays the results graphically.


This week, the genome browser team at the University of California, Santa Cruz, released Track Data Hubs, a new feature for the UCSC Genome Browser.

These hubs are web-accessible directories of genomic data that can be viewed on the browser alongside native annotation tracks. It provides access to datasets and lets users display tracks from any public track hub that has been registered with UCSC. Additionally, users can import data from unlisted hubs or can set up, display, and share their own track hubs.

The data that underlies the tracks in a hub lives on a remote server and is stored in compressed binary indexed files in bigBed, bigWig or BAM formats. As such, when a hub track is displayed in the browser, only the data needed to support the view of the current genomic region is transmitted, rather than the entire file.


The Scan

Driving Malaria-Carrying Mosquitoes Down

Researchers from the UK and Italy have tested a gene drive for mosquitoes to limit the spread of malaria, NPR reports.

Office Space to Lab Space

The New York Times writes that some empty office spaces are transforming into lab spaces.

Prion Pause to Investigate

Science reports that a moratorium on prion research has been imposed at French public research institutions.

Genome Research Papers on Gut Microbe Antibiotic Response, Single-Cell RNA-Seq Clues to Metabolism, More

In Genome Research this week: gut microbial response to antibiotic treatment, approach to gauge metabolic features from single-cell RNA sequencing, and more.