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Downloads and Upgrades: Jan 14, 2011


This week, Selventa announced that the latest versions of its software tools, the Hypothesis Investigation Suite and the Model Investigation Suite, are now available.

According to the developers, these tools contain an interoperable set of applications that support integrated workflows for generating and investigating biological mechanisms derived from large volumes of experimental data. The suites are available as bundled products, individual modular applications, and as web-accessible licensed software programs for Selventa's academic, pharmaceutical, and biotechnology partners.

Included in the Hypothesis Investigation Suite are the project manager and project workbench applications, which enable users to load large volumes of experimental data as well as to generate and analyze mechanistic hypotheses. The Model Investigation Suite contains model viewer, model analyzer, and model editor applications, which provide users with tools for building, analyzing, and reporting biological models and their interactions.

Genedata has launched version 9 of Genedata Screener, its data analysis software.

According to the developers, the tool contains a high content analyzer that is integrated with several image storage solutions including PerkinElmer’s Columbus Image Data Management and Analysis System and Thermo Scientific Store database. It also includes a kinetics analyzer that imports data from all time-resolved screening instruments, including label-free and automated electrophysiology experiments, and provides interactive access to kinetics traces as well as custom curve analysis methods. Furthermore, the Condoseo application lets users manage multiple dose-dependent high-content screening features in parallel and display original HCS images alongside the dose-response curves as well as process multiple assays.

Life Technologies has launched LifeScope Genomic Analysis a software platform that lets users analyze next-generation sequencing reads from the SOLiD platform.

The tool features push-button workflows that let users map and detect genomic variation, supports the Exact Call Chemistry module of the 5500 Series SOLiD sequencers, and provides project management capabilities.

This week, ChemDiv released E-Commerce, an inventory of small molecules that is supported by MolSoft.

According to the developers, E-Commerce provides access to ChemDiv's discovery chemistry collection, which contains more than 1.5 million screening compounds and a collection of building blocks comprised of more than 10,000 structures. The tool’s search engine lets users search for compounds by drawing a structure or a part of a structure, entering sample ID number, using SMILES, uploading SD-files or Mol-files, and by entire templates. Users are also able to retrieve entire sub-libraries of compounds synthesized around any given template, among other features.

The National Center for Biotechnology Information has launched a new Blast page for its SNP database. Interested users can access the page here.

According to the developers, the new dbSNP BLAST page provides users with access to several different organisms and lets users confirm whether a novel SNP has been reported in the database using flanking sequences or determine if a sequence includes any variations stored in dbSNP, among other tasks.

Also, RefSeq 45 is available via FTP from NCBI.

This full release incorporates genomic, transcript, and protein data available as of Jan. 7 and includes 16,748,646 records, 11,934,213 proteins, and sequences from 11,536 different organisms

Syngene has unveiled its GeneSys image acquisition software, which was developed for use with the company’s G:BOX and Dyversity imaging systems. The software lets users capture 1D, 2D, and multiplex gel images.

Syngene said that GeneSys features large touch-screen buttons that guide users through the setup and image-capture process. Users can select the type of gel or blot they are using and what it is stained with and the software analyzes available filter and lighting options. Then, drawing on a database containing manufacturers' recommended conditions for detection of DNA, RNA, and protein dyes, the software selects the optimal combination for imaging.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.