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Downloads and Upgrades: Oct 29, 2010

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This week, Tripos released Sybyl-X Version 1.2.

The latest release of the molecular modeling suite focuses on streamlined workflows for life science researchers and includes a new, project-oriented interface for quantitative structure-activity relationship studies.

Additionally, the developers have added Surflex-Dock's fragment-constrained docking and treatment of protein flexibility, which the company said will allow scientists to more closely approximate real-world conditions and to use known information about particular fragment placements to guide docking.


The National Center for Biotechnology Information has launched Images, a database of more than 2.5 million images and figures from medical and life sciences journals.

According to the developers, Images will have a wide range of uses for a variety of groups such as clinicians looking for visual representations of a disease or condition, researchers searching for studies with certain types of analyses, students seeking diagrams that elucidate complex processes such as DNA replication, professionals or educators looking for images for presentations, and patients wanting to better understand disease.

The database lets users search images based on keywords and other parameters, such as author and publication date, and save them. Users can also share saved images and data with others through the My NCBI feature, which allows users to customize their search and display preferences, and build bibliographies, among other functions.

The resource currently contains images and figures contained in NCBI's PubMed Central full-text digital archive of biomedical and life sciences journal literature and may be expanded to include other NCBI resources, such as the Bookshelf database of biomedical books and reports.


SoftGenetics has released an updated version of its genotyping software, GeneMarker.

The developers said that the latest version of the software includes a new module for comparative analysis of cystic fibrosis types for use with Gen-Probe’s Elucigene CF kit as well as visualization of mutant alleles generated by the Abbott Cystic Fibrosis Genotyping assay. The new release also includes a user-management tool that controls access rights and provides an analysis audit trail.

Other new features include a macromolecules analysis module for analyzing carbohydrates, polysaccharides, proteins and polypeptides, without the use of an internal size standard; and two new sizing algorithms that allow for linear sizing of DNA fragments from 20 bp to more than 1000 bp, as well as the sizing of nonlinear data.

The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.