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Downloads and Upgrades: Oct 22, 2010

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GenBank 180.0 is available via FTP from the National Center for Biotechnology Information.

Uncompressed, GenBank 180.0 flatfiles require roughly 457 gigabytes for sequence files only or 490 gigabytes to include the short directory, index, and text files. The ASN.1 data requires approximately 375 gigabytes.


This week, Amazon Web Services announced that beginning Nov. 1, developers can take advantage of a new free usage tier for a full year.

Customers will be able to run the free Amazon EC2 instance for a year, which includes a free usage tier for Amazon S3, Amazon Elastic Block Store, Amazon Elastic Load Balancing, and AWS data transfer.

According to the company, developers can use the free access to launch new applications, broaden their AWS knowledge, or simply gain hands-on familiarity with the services. If a new application spikes in popularity, it will scale and run on AWS’s pay-as-you-go system at standard pricing.

Amazon's offer includes:

•750 hours per month of micro Linux Amazon EC2 instance usage — enough to run continuously
•750 hours per month of an Amazon Elastic Load Balancer
•10 GB per month of Amazon Elastic Block storage
•5 GB per month of Amazon S3 storage
•30 GB per month of internet data transfer (15 GB of data transfer “in” and 15 GB of data transfer “out” across all services)
•25 machine-hours per month of Amazon SimpleDB
•100,000 requests per month for Amazon Simple Queue Service
•100,000 requests per month, 100,000 notifications over HTTP per month, and 1,000 notifications over e-mail per month for Amazon Simple Notification Service


BioRuby 1.4.1 is available here.

The new release fixes bugs that existed in version 1.4.0 and includes improved support for PAML Codeml result parser, new test codes and improvements to existing code, and two new parsers, among other features.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.