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DoubleTwistAnnotated Human Genome Database, Prophecy Genes; Carlsberg Research Center DNATools; Imaging Research- ArrayStat; Weizmann Institute- GeneCards.


DoubleTwist has released an upgraded version of its Annotated Human Genome Database. The Oakland, Calif.-based company said the updated system incorporates more than 3 billion human DNA base pairs, 500,000 SNPs, and 100,000 STSs.

The database can be accessed through or licensed for on-site installation through DoubleTwist’s Prophecy database and toolkit.

DoubleTwist also released Prophecy Genes, a non-redundant set of human genes that includes summary cards, confidence ratings, and support for each gene prediction.

The most recent version of the sequence analysis software DNATools is available at DNATools was developed by the department of yeast genetics at the Carlsberg Research Center. It includes functions for batch renaming, sequence editing and annotation, restriction mapping, translation, batch Blast search, codon analysis, and primer design and ordering.

Special functions are also included for handling and analysis of small EST projects and SAGE data.

Imaging Research, a majority-owned subsidiary of Amersham Pharmacia Biotech located in St. Catharines, Ontario, has released ArrayStat software to provide statistical analysis of gene expression array data.

The company said the program analyzes data from a variety of array data file formats and requires as few as two replicates per spot.

The software integrates with Imaging Research’s ArrayVision array quantification program.

Release 2.19 of the Weizmann Institute’s GeneCards database is now available at

The new release contains 18,583 genes and 36 gene clusters, of which 11,980 genes have symbols approved by the HUGO gene nomenclature committee. It also incorporates data from version 2.0 of the unified database (UDB), which integrates genomic contigs from NCBI with the UDB map.

Since the last GeneCards release, two additional GeneCards mirror sites have been established: at the Genome Sequence Center of the British Columbia Cancer Agency and at St. Jude Children’s Research Hospital.


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