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DoubleTwist-SNPTwist, Prophecy ToolKit; Compugen- Z3; BioDiscovery- GeneSight; Media Cybernetics- Array-Pro Analyzer; Phase-1 Molecular Toxicology- Toxbank; Interactions Ontology.


Two new products from DoubleTwist, SNPTwist and the Prophecy ToolKit, were launched last week.

SNPTwist software enables high-throughput detection of SNPs within large sequence databases. The Prophecy ToolKit is a suite of Unix-based software programs that allows users to integrate DoubleTwist’s annotated human genome data with proprietary sequence data.

Compugen has released the latest version of its Z3 automated 2D gel analysis system. New features include the capability to create one image from several gels of the same sample, an advanced protein annotation feature, and the ability to predict the mass of protein components of the sample.

The new version supports Windows 200, Windows 98, and NT 4.0.

The newest version of BioDiscovery’s GeneSight data mining system offers a new approach to array data analysis, the company said. GeneSight version 2.0 uses advanced statistical models and multivariate tools to analyze large sets of data files resulting from array experiments.

Media Cybernetics has also released new microarray analysis software. Array-Pro Analyzer allows users to adjust control parameters in order to optimize signal/noise and offers statistical user feedback.

A comprehensive rat toxicology database, Toxbank, is now available from Phase-1 Molecular Toxicology. The database includes an updated version of the company’s gene expression data analysis software suite, Matrixexpress.

Phase-1 has identified 700 rat genes whose expression changes significantly as a function of toxic stimuli. Toxbank contains gene expression and toxicology data based on exposure to 55 compounds. Phase-1 plans to analyze 75 additional compounds in 2001, releasing new data every four months.

Peter Karp and Suzanne Paley of SRI International have posted the first draft of the Interactions Ontology for comment. The ontology is meant to serve as a common framework for exchanging data about metabolic reactions and small molecules. The draft is available online (

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