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DomainNetworkBuilder, Reactome version 15, MDL Logistics, HapMap Public Release 18, dbSNP build 125, Greg Kinch, Rob Milne, David Slater-Kinghorn, Brandie Yarish, James DeGreef, Michael Ball, David Haussler


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The Max Planck Institute for Informatics has released DomainNetworkBuilder, a Cytoscape plug-in that decomposes protein networks into domain-domain interactions. According to the developers, the software transforms each protein node into a chain of consecutive domain nodes and constructs a putative network of interacting domain nodes. The plug-in is available at, and will also be available through the Cytoscape site at

The Reactome project at Cold Spring Harbor Laboratory and the European Bioinformatics Institute has released Reactome version 15 at The release includes 1,463 total reactions and 1,095 annotated human proteins. New features include a module on the integration of energy metabolism, a revised data model to improve the handling of physical entities, and a new strategy for electronic inference of events in model organisms from curated human reactions.

Elsevier MDL has launched MDL Logistics, a reagent procurement and inventory management application that streamlines the process of locating, purchasing, and tracking chemical materials. MDL Logistics provides access to the MDL Available Chemicals Directory database as well as to in-house inventory.

The HapMap Data Coordination Center at Cold Spring Harbor Laboratory has posted HapMap Public Release 18, which includes Phase II data from the HapMap project, at The release includes data from 6 chromosomes — 2, 6, 11, 14, 15, and 21 — as well as all processed genotypes from Phase I and II on these chromosomes. The data is the complete set for the YRI and CEU samples, but the data is incomplete on Phase II for the JPT and CHB samples.

The National Center for Biotechnology Information has released dbSNP build 125 at The release includes 15,579,132 new submissions for 14 organisms, and a total of 47,736,233 submissions.

People in the News

GenoLogics has added several people to its management team "to support the business expansion and growth strategy of the company." Greg Kinch, who most recently worked at Silicon Genetics, joins the firm as vice president of sales. Kinch previously held sales positions at Genomic Solutions and BI Systems. Rob Milne, hired as vice president of product development, previously held engineering and R&D executive positions with Nokia, Vienna Systems, Motorola, and Mitel. Gail McBride, vice president of marketing, comes from a marketing position at A.L.I. Technologies (now owned by McKesson) and marketing and international business development roles at H.A. Simons Ltd. (now AMEC). David Slater-Kinghorn, who has joined as vice president of finance, previously held operational management positions at LifeScan Canada, a Johnson & Johnson company, CanWel Distribution, and Sappi Export Services. Brandie Yarish, manager of human resources, comes from Power Measurement and ACD Systems. Finally, James DeGreef, a company co-founder who led the start-up and development of the company until the appointment of Michael Ball as CEO last September, has assumed the role of vice president of product management.

David Haussler, professor of biomolecular engineering at the University of California, Santa Cruz, has been tapped to receive Carnegie Mellon University's Dickson Prize in Science. Haussler will receive an award of $50,000 and will deliver a public lecture as part of the prize ceremony to be held at Carnegie Mellon in March. Haussler directs the Center for Biomolecular Science and Engineering at UCSC and is scientific co-director of the California Institute for Quantitative Biomedical Research. The Dickson Prize was established by a gift to Carnegie Mellon from the estate of Dr. and Mrs. Joseph Dickson to fund an annual prize to "persons who have made outstanding contributions to science in the United States," Carnegie Mellon said.

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The Scan

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A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.