WALNUT CREEK, Calif.--Researchers at the Department of Energy's Joint Genome Institute here have completed working drafts of the DNA sequence of human chromosomes 5, 16, and 19. The chromosomes contain an estimated 10,000-15,000 genes. Data analysis was done by the Computational Bioinformatics group at Oak Ridge National Laboratory. All data have been deposited in GenBank. Working drafts for the remaining human chromosomes are expected later this spring from other participants in the Human Genome Project.