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Delaware Wins NSF Funds for Protein Informatics Resource

NEW YORK (GenomeWeb News) – The University of Delaware has won a $1.6 million grant from the National Science Foundation to establish a centralized bioinformatics resource focused on proteins.

Under the four-year grant from NSF's Advances in Biological Informatics Program, UD Professor Cathy Wu will develop a new bioinformatics research infrastructure that will provide the plant research community with knowledge about the biochemical modifications of proteins and their functions.

The resource will pull together large volumes of data that is publicly available from various disparate resources into one place by integrating text mining, data mining, analysis, and visualization, as well as ontologies and databases.

The project is an interdisciplinary research collaboration facilitated by the UD Center for Bioinformatics and Computational Biology.

"Our development of a text mining system will focus on mining full-length articles for PTM-related information," Vijay Shanker, a professor of computer and information sciences at UD, said in a statement. "The work will involve developing new techniques for extracting information from individual sentences and for putting together pieces of information extracted from different sections of an article. Information extracted from tens of thousands of articles will then be made available to biologists as well as data mining programs."

Wu also was awarded $3.2 million from the National Institutes of Health through a renewal grant for research that will continue development of the Protein Ontology reference library, which aims to provide a structured representation of the types of protein classes that reflect evolutionary relatedness, protein forms resulting from alternative splicing, mutations, and PTMs, as well as protein complexes, and a precise definition of their relationships.

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