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The DDT Launching Pad: Informatics Products at Drug Discovery Technology 2004

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GeneGo launched MetaCore 2.0, which includes more than 300 functional maps of human biology, parsers for importing data directly from Affymetrix and Agilent microarrays, and data from Silicon Genetics’ GeneSpring, Rosetta’s Resolver, SAGE, proteomics, and metabolomics data. MetaCore 2.0 also has seven new network-building algorithms, and additional visualization tools.


InforSense launched a new version of the BioScience module for its Knowledge Discovery Environment workflow management platform. The new version of the module offers extended visualization and interpretation capabilities, new workflow components, enhanced external data connectivity, and further facilitates the integration of Perl scripts and applications into InforSense workflows, the company said. The module includes FeatureVista, a new sequence and annotation browser, and the XML Integration Framework Studio for incorporating command-line tools.


Ingenuity Systems announced the “Summer ‘04” release of its Ingenuity Pathways Analysis product, along with a new Ingenuity Enterprise Collaboration application for pharmaceutical and biotechnology companies, an Ingenuity Workgroup Collaboration application for government and non-profit institutions, and Ingenuity University — a two-day course that teaches “best practices” and use of pathways analysis in drug discovery and development. The new release of the company’s flagship product offers a number of new features, including a network comparison capability that allows users to compare up to ten networks; global functional analysis for graphically displaying biological processes across multiple datasets; network merging; and simultaneous analysis of gene and protein experiments. The Enterprise and Workgroup collaboration applications are currently in development. The company said it is seeking beta-testers for these applications, which should be released in the fourth quarter of the year.


Ocimum Biosolutions launched its Pharmatracker LIMS. The system is compliant with GxP requirements as stipulated by the US EPA, US FDA, and WHO, as well as the FDA’s 21 CFR Part 11 requirements on electronic records and electronic signatures. Workflow, stability, QC batch management, and trend analysis tools are provided as part of the system.


Optive Research launched EA-Inventor, a de novo molecular design program based on an evolutionary algorithm that allows chemists to “evolve” new compounds by modifying the structures of an initial set of compounds. Optive said that the software can work with whatever fitness function best describes a user’s specific constraints and discovery objectives. EA-Inventor can work with any third-party scoring function, the company said, and ships with several scoring functions developed by Optive Research.


Spotfire released DecisionSite 8. The new version of the company’s software includes a shared repository for analysis guides, files, and posters, and a SmartLists feature that tracks critical elements such as leads, prospects, lots, and batches. The company also launched the Spotfire DecisionSite Analytics Server, which enables DecisionSite 8 to access data from disparate databases and also links statistics engines from Insightful S-Plus and R into the DecisionSite 8 environment. DecisionSite 8 is available with no additional license fee to all DecisionSite customers under maintenance agreements .

 

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The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.