NEW HAVEN, Conn.--CuraGen said it has been granted a second US patent covering its open architecture technology for discovering genes, measuring gene expression, and enabling pharmacogenomics research. Specifically, the company said the new patent covers the apparatus and computer systems utilized in its GeneCalling system, which was discussed in a peer-reviewed paper published in the August, 1999, issue of Nature Biotechnology. GeneCalling is a high-throughput method for analyzing differences in gene expression and gene sequence and comparing results to public and proprietary sequence databases.