Comparative Sequence Assembly Emerges as Shotgun Shortcut; First Product on the Market | GenomeWeb

Lior Pachter describes comparative sequence assembly with the simplest of analogies: “If you’re working on a jigsaw puzzle, you’re better off working by looking at the front cover of the box so you have a clue where the pieces should go.” Likewise, assembling the tiny fragments of a newly shotgunned genome is much simpler when you have the complete picture of a pre-assembled genome to serve as a guide.

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