Lior Pachter describes comparative sequence assembly with the simplest of analogies: “If you’re working on a jigsaw puzzle, you’re better off working by looking at the front cover of the box so you have a clue where the pieces should go.” Likewise, assembling the tiny fragments of a newly shotgunned genome is much simpler when you have the complete picture of a pre-assembled genome to serve as a guide.

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Researchers report that deleting one gene from butterflies affects their wing coloration patterns, according to the Washington Post.

The Seattle Times writes that pharmacogenomics testing can help choose medications that may work best for people with depression.

In PNAS this week: genome sequencing of weevil symbionts, retinoid X receptor deletion in lung cancer metastasis, and more.

Sequencing could help combat foodborne illnesses, according to a blog post by Food and Drug Administration officials.