SAN DIEGO--CombiChem, a computational drug discovery company here, has named two scientists to management positions. Klaus Gubernator was appointed vice-president of special projects, and Robert Zambias will be director of chemistry automation. The two are both members of a technology research group led by Steven Teig, CombiChem's vice-president for advanced technology.
Gubernator formerly directed the molecular design and bioinformatics section in pharmaceutical preclinical research at Hoffman-LaRoche's research facility in Basel. Among other things, he led the development and application of structure-based design and bioinformatics technologies there. Zambias was previously at ArQule, where he served as executive director of automated synthesis, leading the design, construction, and implementation of the company's automated chemistry program and forming the company's Automated Synthesis Engineering and Chemistry Groups.
CombiChem uses its proprietary Discovery Engine process to focus on the generation, evolution, and optimization of potential new lead candidates for its collaborative partners, who include Teijin, Roche Bioscience, Sumitomo Pharmaceuticals, ImClone Systems, and Athena Neuroscience.