NEW YORK (GenomeWeb) – Picking an accurate and cost-effective pipeline for analyzing sequence data is critical as sequencing becomes standard practice in research and clinical contexts. To evaluate the robustness of existing variant detection pipelines and offer insights into the sort of compute resources required to run these tools, researchers from Spain's National Centre for Genomic Analysis-Centre for Genomic Regulation (CNAG-CRG) and elsewhere recently benchmarked different combinations of read aligners and variant callers for whole-genome and whole-exome sequencing.