Skip to main content
Premium Trial:

Request an Annual Quote

CHB Kicks Off $25K Challenge to Set Standards for Clinical Genomic Data Interpretation


Children's Hospital Boston this week launched a competition intended to "advance standards for genomic analysis and interpretation and the reporting of clear, actionable results to clinicians and patients."

With a $25,000 prize at stake, participants in the Children’s Leadership Award for the Reliable Interpretation and appropriate Transmission of Your genomic information, or CLARITY, contest will be given the task of identifying the genetic roots of unnamed disorders in three pediatric patients at CHB's Manton Center for Orphan Disease Research.

The hospital will accept applications from academic and commercial groups until March 1. It will then select a maximum of 20 teams to compete in the challenge.

The groups that are selected to participate in the challenge will be notified in April at which time the contest will officially begin and will last for about four months, CHB said.

Competitors will receive de-identified clinical summaries and genomic and/or exomic sequences — generated by the challenge sponsors Complete Genomics and Life Technologies — for the three children and their families.

Each child has a disorder that, based on clinical manifestations and family histories, suggests a currently unknown genetic basis. Competitors are expected to develop analyses, interpretations, and reports that putatively identify the genomic features responsible for each child’s disorder as well as provide meaning and context that would allow physicians and families to make sense of the results and help guide healthcare decisions.

Specifically, participants will be asked to identify the best methods for analyzing the data, identifying disease-causing mutations related to the patients' phenotypes, and reporting relevant information back to clinicians in a written format.

As part of the process, participants are expected to come up with best practices for interpreting and presenting sequence results to patients, their families, and physicians, CHB said.

Contestants are expected to submit their methods, results, and a written clinical report that will be evaluated by a panel of judges. The winning team will be announced in October.

The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.