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Blackstone Computing, CDC Solutions, Bernard Pallson s lab, Integrasoft


Blackstone to be Reborn as Argentys

Blackstone Computing has been acquired by a firm called Argentys, CFO Kevin Ehrlich confirmed recently, but he was unable to disclose further information about the new company. “Argentys is a separate business that acquired the Blackstone business, and that company is deep in [the process of] considering a variety of avenues and approaches, so we don’t have a lot to say about that right now,” Ehrlich told BioInform.

Marc Dulude, a senior partner with Ampersand Ventures, a VC firm that invested $12.6 million in Blackstone in 2001, is listed as Argentys’ CEO on the company website. Neither Shiv Tasker, appointed CEO in the fall of 2002, nor his predecessor, Brian Ritchie, who was made vice president of business development upon Tasker’s appointment, are listed as part of the management team.


Report Indicates Low CFR-11 Compliance

A recent survey by Philadelphia-based CDC Solutions indicates that only 7 percent of the 105 responding life science companies are currently using a purely electronic submissions system, while 37 percent are using a purely paper-based system, and 34 percent are using a combination of paper and electronic submissions.

Nearly 60 percent of respondents said they plan to increase their use of regulatory submissions software, and almost 20 percent said they plan to implement a full electronic submissions system in 2003.

In terms of 21 CFR 11 compliance, 11 percent of respondents indicated they were compliant with 21 CFR Part 11, and 42 percent said they are planning to become compliant.


Researchers Model Gene Function in Yeast

Bernard Pallson’s lab at the University of California San Diego and collaborators at the Technical University of Denmark have created a computer model to simulate gene function and cellular metabolism in Saccharomyces cerevisiae.

The mathematical model is able to simulate 1,175 reactions produced by 708 genes interacting with 723 metabolites and represents the first predictive genome-scale model for a eukaryotic cell, according to the researchers.

Six researchers gathered information from databases, books, and scientific journals to build the predictive model. A second, improved, version of the model is expected to be complete within a few months.

Details of the project are available in the February 2003 issue of Genome Research.


Integrasoft to Host Data Grid Users Group

Integrasoft, a New York-based systems integrator that specializes in distributed trading systems for the financial services market, is expanding its reach into data management systems for grid computing architectures, and is forming a user group around the topic of data grids.

Recognizing that its technology is applicable to the pharmaceutical industry as well as finance, Integrasoft is inviting Connecticut- and New Jersey-based pharmaceutical firms to drop in to the company’s Manhattan offices to share thoughts and best practices on managing data in a grid-based environment.

The first such meeting will be held Feb. 19, from 3:30 to 5:30. Further information is available at:

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The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.