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BioModels, caGrid, Spotfire 2.1, Screener 5.5

The 10th release of the BioModels Database is available here. The new release includes 52 new models, of which 17 are included in the curated branch of the database. The database now includes 244 models representing 25,731 reactions and around 10,000 cross-references.

The National Cancer Institute’s Center for Biomedical Informatics and Information Technology has released version 1.2 of the caGrid core infrastructure here.
The new version includes several improvements, including a simplified service to handle large-scale data transfer for grid-based queries; integration with the latest releases of the Software Development Kit and the Common Security Module; a new web-based single sign-on framework, called WebSSO; and improvements in the usability of tools.

Spotfire, a division of Tibco Software, has released Tibco Spotfire 2.1. The latest release of the enterprise analytics software includes enhanced application programming interfaces and a “business mashups” capability that enables subject-matter experts “to leverage standard interfaces and business intelligence data to create user experiences … that speed insights and prompt better business decisions,” the company said.
Tibco said it expects to deliver Spotfire 2.1 in May. 

Genedata has released Screener 5.5, an updated version of its enterprise software for high-throughput and high-content screening analysis. Screener 5.5 features “easy integration of pharmacological fit models and advanced functionality for analyzing experiments with multiple readouts,” the company said.

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The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.