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BIOINFORMATICS BRIEFS: Apr 29, 2002

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LabBook Teams with CambridgeSoft and Scientific Software

LabBook of McLean, Va., expanded its partner base last week with Scientific Software of Columbus, Ohio, and CambridgeSoft of Cambridge, Mass.

Scientific Software’s CyberLab Knowledge Engineering System will be integrated into LabBook’s eLabBook electronic research notebook. The combined solution will offer a single electronic workspace that the companies said will address the needs of both bench scientists and pharmaceutical research organizations.

CambridgeSoft, meanwhile, will integrate its ChemOffice software with eLabBook, adding small-molecule data handling to LabBook’s platform.

 

Incyte Taps GeneFormatics and Accelrys for Functional Annotation of Proteins

Incyte Genomics last week enlisted the aid of both GeneFormatics and Accelrys to provide functional annotations for its proprietary protein sequences.

GeneFormatics will use its “integrated” structural proteomics approach, which derives protein structures through both experimental and computational techniques, to characterize potential therapeutic and target proteins at Incyte.

Separately, Incyte said it is using the GeneAtlas application from Accelrys to computationally predict and annotate protein structures. Accelrys is also providing Incyte with its Atlas Store relational database to store protein 3D annotations. In addition, Incyte will become the first customer for Accelrys’ Discovery Studio suite of integrated data mining applications to view the structures.

Incyte spokesman Paul Chirico said the company was annotating the proteins primarily for its in-house discovery work, but is considering making the annotated data available through its information offerings in the future.

 

IBM Opens Grid Innovation Center in France

IBM has opened a “Grid Innovation Center” in Montpellier, France, to showcase its own grid computing technology as well as that of its partners. As part of this effort, IBM has invited Avaki and Platform Computing to demonstrate their grid-based tools to potential customers.

In addition, IBM’s life sciences business unit has purchased multiple licenses of Avaki’s software for internal use as well as for client demonstrations.

 

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The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.