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BioInform s Patent Roundup: Recent Patents of Interest in the Field of Bioinformatics: Jul 1, 2002


US Patent 6,408,308. System and method for generating, analyzing, and storing normalized expression datasets from raw expression datasets derived from microarray includes nucleic acid probe sequences. Inventors: Timothy Maslyn, Srikar Rao, Benjamin Cocks, Rachel Cheng, Timothy Engler, James Kerr, Steven Lassagne, Jeffrey Seilhamer. Assignee: Incyte Pharmaceuticals (now Incyte Genomics).

Protects a processing system for biomolecular expression information comprising procedures and tables that store abundance datasets and hybridization data. The tables also store information identifying a microarray technology type for each hybridization and microarray design information for each microarray technology type.


US Patent 6,408,292. Method of and system for managing multi-dimensional databases using modular-arithmetic based address data mapping processes on integer-encoded business dimensions. Inventors: Reuvan Bakalash, Guy Shaked. Assignee: Hyperroll.

Covers a method for managing data elements in a multidimensional database supported upon a parallel computing platform. The system uses a modular-arithmetic-based address data mapping mechanism to uniformly distribute the data elements among the processors for balanced loading and processing. According to its inventors, the method can be used for online analytical processing, online information searching, or real-time control of processes in response to complex states of information reflected in the multidimensional database.


US Patent 6,401,043. Variance scanning method for identifying gene sequence variances. Inventors: Vincent Stanton, Robert Mark Adams, David Steffen. Assignee: Variagenics.

Covers methods for the computational analysis of genetic variances in the coding and non-coding regions of particular genes. Algorithms are applied to a collection of overlapping DNA sequences obtained from different subjects. According to Variagenics, the “sequence scanning” aspect of its method allows it to identify potentially valuable polymorphisms by distinguishing them from sequencing errors or other experimental artifacts. The patent brings the number of US patents issued to or licensed by Variagenics to 24.


US Patent 6,393,367. Method for evaluating the quality of comparisons between experimental and theoretical mass data. Inventors: Chao Tang, Wenzhu Zhang, David Fenyo, Brian Chait. Assignee: Proteometrics (now Genomic Solutions).

Protects a method for determining the probability that a biological molecule is identified incorrectly for a chosen significance level. Experimental mass data of an unknown biological molecule is compared with theoretical mass data, and a score for each comparison is calculated. At least two of those scores are then selected to form a primary data set, which is then used to determine the probability that the biological molecule identification is incorrect.


US Patent 6,389,428. System and method for a precompiled database for biomolecular sequence information. Inventors: Philippe Rigault, Anne Curtis, Richard Goold, David Hadley, Harold Hibbert, Tod Klingler, Robert Lagace, Laura Stuve, Michael Walker, Michael Wood. Assignee: Incyte Pharmaceuticals (now Incyte Genomics).

Protects a biomolecular database system that uses a set of entities to store attributes for additional entries. At least one attribute is stored in an array, which stores data associated with an entry. An “entity offset” is used to designate the location of the data in the array and to access data associated with a particular entry for all attributes within the entity.

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The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.