US 6,356,863, Virtual network file server. Inventor: Roger Sayle (no assignee).
Covers “a virtual file server for generating content data in response to computer operating system requests involving a remote file system.” According to the patent, the virtual file server receives a request via any of a variety of standard protocols, and content data is translated into the format specified by the request. The virtual file content is not required to be stored as a physical file in the requested format. This approach should be of particular interest in biological sequence database management, according to the inventor, due to the diversity of file formats that must be maintained and the common practice of storing multiple copies of frequently updated databases.
US 6,355,450, Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof. Inventors: Robert Fleischmann, Mark Adams, Owen White, Hamilton Smith, Craig Venter. Assignee: Human Genome Sciences.
Covers “the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO: 1,” in addition to “the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.” Includes over 1,700 protein-encoding fragments of the genome and identifies regulatory elements that modulate the expression of the protein-encoding fragments.
US 6,351,712, Statistical combining of cell expression profiles. Inventors: Roland Stoughton, Hongyue Dai. Assignee: Rosetta Inpharmatics.
Includes “a method for calculating the individual errors associated with each measurement made in nominally repeated microarray experiments,” which can be used in conjunction with rank-based methods to determine whether a cellular constituent is up or down regulated in response to a perturbation.