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BioInform s Patent Roundup: Recent Patents of Interest in Bioinformatics: Jun 9, 2003

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US Patent 6,571,230. Methods and apparatus for performing pattern discovery and generation with respect to data sequences. Inventor: Laxmi Parida. Assignee: International Business Machines.

Describes a method for detecting repeating patterns in an input data sequence. The invention provides that, for any sequence, there exists only a linear number of special motifs and every other motif can be generated from these so-called “irredundant” motifs.

 

US Patent 6,571,227. Method, system and computer program product for non-linear mapping of multi-dimensional data. Inventors: Dimitris Agrafiotis, Victor Lobanov, Francis Salemme. Assignee: 3-Dimensional Pharmaceuticals.

Covers a scalable computer system for dimensionally reducing multi-dimensional data sets. The method determines one or more non-linear functions between a sample of points from the multi-dimensional data set and a corresponding set of dimensionally reduced points, and then uses the non-linear function to non-linearly map additional points.

 

US Patent 6,571,199. Method and apparatus for performing pattern dictionary formation for use in sequence homology detection. Inventors: Aris Floratos, Isidore Rigoutsos. Assignee: International Business Machines.

Covers a computer-based method of processing a plurality of sequences in a database. The method first evaluates each of the plurality of sequences, including characters that form each sequence. Then, at least one pattern of characters is generated representing at least a subset of the sequences in the database. The statistical significance of the pattern is then determined by a value representing a minimum number of sequences that the pattern supports in the database.

 

US Patent 6,567,540. Method and apparatus for providing a bioinformatics database. Inventors: David Balaban, Arun Aggarwal. Assignee: Affymetrix.

Protects a system and method for organizing information relating to polymer probe array chips, including oligonucleotide array chips, using a database model to organize information relating to sample preparation, chip layout, application of samples to chips, scanning of chips, expression analysis of chip results, etc.

 

US Patent 6,564,151. Assigning protein functions by comparative genome analysis of protein phylogenetic profiles. Inventors: Matteo Pellegrini, Edward Marcotte, Michael Thompson, David Eisenberg, Robert Grothe, Todd Yeates. Assignee: The Regents of the University of California.

Describes computational systems for inferring functional links from genome sequences. One method is based on the observation that some pairs of proteins have homologs in another organism fused into a single protein chain that can be revealed by a trans-genome comparison. Another method compares the genomic sequence of two or more organisms to create a phylogenetic profile for each protein, indicating its presence or absence across all the genomes.

 

US Patent 6,560,542. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins. Inventors: Arnold Mandell, Karen Selz, Michael Shlesinger. Assignee: the Cielo Institute.

Protects algorithms for designing peptides or peptide analog molecules capable of binding to and/or modulating the function of protein targets having known amino acid sequences. The methods use three kinds of templates to produce the peptides.

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The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.