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BioInform s Patent Roundup: Recent Patents of Interest in Bioinformatics: May 5, 2003


Patent 6,554,987. Method and apparatus for alignment of signals for use in DNA base calling. Inventors: Rodney Gilchrist, Vrijmoed Chi. Assignee: Visible Genetics.

Protects a method of aligning data traces from a four-channel automated electrophoresis detection apparatus. An optimization routine such as a simulated annealing algorithm is used to determine coefficients of stretch and shift in order to normalize and align the data traces.


US Patent 6,553,317. Relational database and system for storing information relating to biomolecular sequences and reagents. Inventors: Stephen Lincoln, Tod Klingler, Landes Wong, Scott Panzer, David Hodgson, Laura Ito, Andrew Ament, Richard Cathcart, Helen Jolley, Ingrid Akerblom, Brian McKelligon, Mayank Thanawala. Assignee: Incyte Pharmaceuticals (now Incyte).

Protects relational database systems for storing biomolecular sequence information and biological annotations detailing the source of the sequence information and associated reagent information. The reagent information identifies genetic information and materials that are available to users of the database for further applications in research, therapeutic pharmaceutical development, or other fields.


US Patent 6,546,340. Computer-aided probability base calling for arrays of nucleic acid probes on chips. Inventors: Robert Lipshutz, Michael Walker. Assignee: Affymetrix.

Covers a computer system for analyzing nucleic acid sequences. The computer system calculates probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Information from multiple experiments is also used to improve the accuracy of calling unknown bases.


US Patent 6,542,858. Pharmacokinetic-based drug design tool and method. Inventors: George Grass, Glen Leesman, Daniel Norris, Patrick Sinko, John Wehrli. Assignee: Lion Bioscience.

Covers a pharmacokinetic-based tool for predicting absorption of an administered compound of interest. The tool includes several computer-readable components, including an input/output system, a physiologic-based simulation model of one or more segments of a mammalian system having one or more physiological barriers to absorption, and a simulation engine that employs a differential equation solver. The invention also provides methods for predicting in vivo absorption and other properties from either in vitro or in vivo data.


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