Patent 6,554,987. Method and apparatus for alignment of signals for use in DNA base calling. Inventors: Rodney Gilchrist, Vrijmoed Chi. Assignee: Visible Genetics.
Protects a method of aligning data traces from a four-channel automated electrophoresis detection apparatus. An optimization routine such as a simulated annealing algorithm is used to determine coefficients of stretch and shift in order to normalize and align the data traces.