US Patent 6,620,591. System for cell-based screening. Inventors: Terry Dunlay, Lansing Taylor. Assignee: Cellomics.
Protects an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening compounds for biological activity. The invention includes a computerized method for processing, displaying, and storing the experimental data.
US Patent 6,615,141. Database system for predictive cellular bioinformatics. Inventors: James Sabry, Cynthia Adams, Eugeni Vaisberg, Anne Crompton. Assignee: Cytokinetics.
Covers a database management system for storing cellular information that includes a population module for categorizing and storing information on cell size, distance between cells, cell population, or cell type from an image acquisition device. The system also has a translation module for defining a descriptor, such as a drug, from a set of selected features.
US Patent 6,613,520. Methods for the survey and genetic analysis of populations. Inventor: Matthew Ashby. Assignee: None.
Covers methods for performing surveys of the genetic diversity of a population, methods for creating databases comprising the survey information, and methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample.
US Patent 6,611,833. Methods for profiling and classifying tissue using a database that includes indices representative of a tissue population. Inventor: Peter Johnson. Assignee: TissueInformatics.
Describes a database that stores structural, mechanical, and/or cell function indices for tissue populations in order to classify tissue specimens as normal or abnormal.
US Patent 6,611,828. Graphical viewer for biomolecular sequence data. Inventors: Alex Koleszar, Jeanette Schmidt, Megan Grether. Assignee: Incyte Genomics (now Incyte Corp.).
Protects methods, media, and systems for graphically displaying computer-based biomolecular sequence information that may include nucleotide or amino acid sequence information or both. The graphical depictions may be in several different formats and may be displayed in one or more screens of a computer user interface.
US Patent 6,611,766. Proteome analysis for characterization of up-and down-regulated proteins in biological samples. Inventors: Peter Larsen, Stephen Fey. Assignee: None.
Protects methods and computer systems for analyzing cell proteomes to characterize proteins that are up- or down-regulated under different conditions, such as under abnormal or compound-treated conditions.
US Patent 6,610,489. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions. Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone. Asignee: Sangamo Bioscience.
Covers methods for identifying a drug target as a component of a signal transduction pathway based on selecting a gene of therapeutic interest, determining the regulatory DNA sequences that regulate expression of the gene in a cell of interest, and reconstructing the signal transduction pathways that act on molecules that bind to the regulatory sequence.
US Patent 6,607,887. Computer-aided visualization and analysis system for sequence evaluation. Inventor: Mark Chee. Assignee: Affymetrix.
Protects a computer system for analyzing nucleic acid sequences by analyzing the fluorescence intensities of hybridized nucleic acid probes.
US Patent 6,606,622. Software method for the conversion, storage and querying of the data of cellular biological assays on the basis of experimental design. Inventors: James Sorace, Gerald Canfield. Assignee: None.
Covers a system to convert, store, and query cellular biological assay data on the basis of experimental design. The system uses a library of data-entry forms for users to retrieve information based on the characteristics and experimental effects of test agents. The system uses a single data model in order to minimize difficulties associated with searching multiple databases and supports a broad range of biological data, including protein or mRNA expression data, as well as functional cellular data such as apoptosis or adherence.