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BioInform s Patent Roundup: Recent Patents of Interest in Bioinformatics: Oct 21, 2002


US Patent 6,466,874. Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences. Inventors: David Eisenberg, Edward Marcotte, Matteo Pellegrini, Michael Thompson, Todd Yeates. Assignee: The Regents of the University of California.

Protects a computational system for inferring functional links from genome sequences. Several methods are covered.


US Patent 6,453,333. Research system using multi-platform object-oriented program language for providing objects at runtime for creating and manipulating biological or chemical data to facilitate research. Inventors: Manual Glynias, Daniel Forsch, Michael Dickson, Joanne O’Dell, Michal Soclof. Assignee: Lion Bioscience.

Covers a computer-based research system in which at least one computer runs a multi-platform object-oriented programming code, and another stores drug-discovery-related data.


US Patent 6,446,011. Tandem repeat detection using pattern discovery. Aris Floratos, Isadore Rigoutsos, Gustavo Stolovitzky. Assignee: IBM

Protects an algorithm that detects tandem repeats in an input sequence.


US Patent 6,446,010. Method for assessing significance of protein identification. Inventors: Jan Eriksson, David Fenyo, Brian Chait. Assignee: Rockefeller University.

Covers a method for generating mass data for a biological molecule and for a series of random hypothetical biological molecules, and then calculating high similarity scores between mass data of each molecule generated.


US Patent 6,459,994. Methods for computer-assisted isolation of proteins. Inventors: Rajesh Parekh, James Bruce, Robin Philp, Lida Kimmel, David Friedman. Assignee: Oxford GlycoSciences.

Protects computer-assisted methods for identifying, selecting, and characterizing biomolecules in a sample using a computer-generated digital profile.


US Patent 6,456,942. Network infrastructure for custom microarray synthesis and analysis. Inventor: Brooke Anderson. Assignee: Combimatrix.

Covers a network infrastructure design that comprises a host server or servers, a microarray synthesizer, a hybridization unit, and a user interface or workstation.


US Patent 6,453,241. Method and system for analyzing biological response signal data. Inventors: Douglas Bassett, Stewart Buskirk, Andrey Bondarenko. Assignee: Rosetta Inpharmatics.

Covers a computer program for the analysis of biological response data. In one embodiment, biological datasets are graphically selected by a user from a viewer window on a computer display, projected onto one or more other viewers on the display, and the selected data is highlighted in destination viewers using contrast or color differentiation.

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The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.