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BioInform s Funding Update: Some Recent NIH Awards in Bioinformatics: Mar 10, 2003


Interdisciplinary Center for Structural Informatics. Start date: Jan. 2003. Expires: Nov. 2005. Amount: $613,444. Principal Investigator: James Brinkley. Institution: University of Washington. NIH Institute: NLM.

Proposal to create an information framework called the Interdisciplinary Center for Structural Informatics that would link diverse types of biomedical data and knowledge in a large-scale distributed information system.


Development of Bioinformatic Tools for Virtual Cloning. Start date: Feb. 2003. Expires: Aug. 2003. Amount: $100,000. Principal investigator: Jeremy Bruenn. Institution: Virmatics. NIH Institute: NIGMS.

Project aims to develop a task-centered virtual cloning expert system that serves as a knowledge base for DNA manipulations, and also to develop an “information automaton” for the construction of expression clone libraries to support structural genomics initiatives and other high-throughput experiments.


A Novel Pattern-Based Framework for Genetic Analysis. Start date: March 2003. Expires: February 2004. Principal investigator: Zhong Li. Institution: First Genetic Trust. NIH Institute: NCI.

Project will develop a data analysis method to map complex traits that consider all possible genetic mechanisms using a pattern discovery-based approach and a collection of theoretically and empirically derived statistics to identify multi-locus disease associations.


Proteomics Software Package for the Detection of Cancer. Start date: April 2003. Expires: Sept. 2003. Principal investigator: Maciek Sasinowski. Institution: Incogen. NIH Institute: NCI.

Phase I SBIR project to develop a software package to diagnose cancer based on classification of proteomics data obtained through mass spectrometry, particularly MALDI/SELDI TOF mass spec data. Initial work will focus on exploring the applicability of various existing statistical approaches for signal conditioning and classification of SELDI proteomics data.


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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.