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BioInform s Funding Update: Some Recent NIH Awards in Bioinformatics: Feb 23, 2004


BindingDB: A Tool for Structure-Based Drug Discovery. Start date: Feb. 2004. Expires: Jan. 2008. Amount: $400,475. Principal investigator: Michael Gilson. Institution: University of Maryland Biotechnology Institute. NIH Institute: NIGMS.

Project to expand the BindingDB database ( to allow users to access binding data from the literature in numerical form, and permit querying according to chemical structure.

Optimization of Folding and Threading Proteins. Start date: Feb. 2004. Expires: Jan. 2008. Amount: $238,062. Principal investigator: Ron Elber. Institution: Cornell University, Ithaca. NIH institute: NIGMS.

Project to develop algorithms for predicting protein structures, focusing on bottlenecks such as the folding energy and the ability of making approximate matches. A prediction server at will be updated as the project progresses.

Statistical Methods for Gene Mapping: a New Paradigm. Start date: Jan. 2004. Expires: Dec. 2006. Amount: $147,500. Principal investigator: Shili Lin. Institution: Ohio State University. NIH institute: NHGRI.

Project will develop a set of statistical methods for mapping disease genes for preliminary genome-scan studies. The method will reverse traditional hypotheses for linkage, which usually set the null hypothesis as being no linkage and the alternative hypothesis being linkage.

Continued Support and Development of SBML. Start date: Feb. 2004. Expires: Jan. 2007. Amount: $284,871. Principal investigator: John Doyle. Institution: California Institute of Technology. NIH institute: NIGMS.

Proposal to support and further develop SBML and related software infrastructure. Specific aims include extending the language with new features, maintaining existing software libraries, and producing documentation.

Strategies for Fast Conformational Searching. Start date: Jan. 2004. Expires: Dec. 2006. Amount: $56,308. Principal investigator: Guo-Hong Wu. Institution: University of California, San Francisco. NIH institute: NIGMS.

Supports computational protein folding and docking using the general Convex Global Underestimator (CGU) method, which provides dynamic under-fitting of the energy landscape. The project will combine the general CGU with a physics-based “zipper method” for folding.

Realistic Protein Folding with Hydrophobic Potentials. Start date: March 2004. Expires: Feb. 2007. Amount: $40,320. Principal investigator: Eugene Shakhnovich. Institution: Harvard University. NIH institute: Fogarty International Center.

Project to determine a potential energy function for ab initio folding simulations. An unspecified hydrophobic potential will be combined with a realistic, off-lattice model, with all protein heavy atoms represented explicitly.

Genomic Database for Candida Albicans. Start date: April 2004. Expires: March 2009. Amount: NA. Principal investigator: Gavin Sherlock. Institution: Stanford University. NIH Institute: NIDCR.

Supports development of the Candida Genome Database (CGD), which will contain annotated information about the Candida albicans genome. CGD will reuse the database structures and software developed for the Saccharomyces Genome Database.

Filed under

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.