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BioInform s Funding Update: Some Recent NIH Awards in Bioinformatics: Jan 19, 2004


AutoDock Software Development and Maintenance. Start date: January 2004. Expires: December 2007. Amount: NA. Principal investigator: Arthur Olson. Institution: Scripps Research Institute. NIH institute: NIGMS.

A proposal to extend the usefulness, usability, and maintainability of the AutoDock biomolecular interaction prediction software package. Goals include restructuring the AutoDock suite into a component-based framework; expanding AutoDock’s capabilities by extending the treatment of molecular representations, search methods, and scoring functions; enhancing the graphical user interface, analysis and visualization tools; and developing support mechanisms for AutoDock users and developers.

Semi-Automated Method for Annotating Repeated Sequences. Start date: February 2004. Expires: January 2006. Amount: NA. Principal investigator: Mitrick Johns. Institution: Northern Illinois University. NIH institute: NIGMS.

Funds development of a graphical method for identifying and annotating repeated sequences found on chromosome-length DNA sequence assemblies. The basic method uses a Blast search of segments of the chromosome against the entire chromosome sequence. The results are then displayed on a “Blast dotplot,” where both the x and y axes represent sections of the chromosome. Repeated sequences are seen as a series of stacked horizontal lines whose position and color shows the chromosomal location and similarity of each repeat.

Defining the Topography of Gene Expression. Start date: June 2004. Expires: NA. Amount: NA. Principal investigator: Katherine Pollard. Institution: University of California, Santa Cruz. NIH institute: NIGMS.

Supports development of several new clustering methods, including the hierarchical ordered partitioning and collapsing hybrid (HOPACH), which combines the strengths of both partitioning and agglomerative clustering methods, for gene expression data analysis. The automated HOPACH algorithm will be written in the R language and will be a contributed package to the R open source statistical software projects.


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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.