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BioInform s Funding Update: NSF Bioinformatics Awards to June 19, 2004


Prediction and Validation of Phospho-Regulatory Sites in Crop Plant Proteomes. Start date: June 2004. Expires: January 2006. Expected total amount: $691,501. Principal Investigator: Jeffrey Harper. Sponsor: University of Nevada, Reno.

Project to use bioinformatics to predict a subset of potentially important sites of phospho-regulation in the rice proteome, and then use a peptide-based experimental strategy to start validating those predictions. Aims include improving bioinformatics tools to identify motifs involved in phospho-signaling in plants; conducting a clustering analysis of all Ser- and Thr-containing sub-sequences in plant proteomes; designing a peptide array platform to profile kinase activities in vitro; and identifying peptides that can disrupt in vivo signaling pathways.

Developing High Throughput Protein Network Analysis to Determine the Function of Unknown Rice Genes. Start date: June 2004. Expires: November 2005. Expected total amount: $199,949. Principal investigator: Richard McCombie. Sponsor: Cold Spring Harbor Laboratory.

Funds a project that will use high-throughput proteomics to determine gene function based on the cellular interaction network of encoded proteins in rice. The information will be captured in a publicly available database that will enable construction of broadly based protein interaction maps of rice.

REU Summer Program in Computational Biology. Start date: June 2004. Expires: August 2007. Expected total amount: $69,961. Principal investigator: Jonathan Bell. Sponsor: University of Maryland Baltimore County.

Funds an eight-week summer course in computational biology for undergraduates. Students will select a research topic from either bioinformatics or computational neuroscience.

Software for Micro RNA Detection and Analysis. Start date: July 2004. Expires: December 2004. Expected total amount: $98,909. Principal investigator: Gary Fogel. Sponsor: Natural Selection.

Phase I SBIR funds development of a neural network method for identifying functional RNA molecules, specifically with extension to eukaryotes. The commercial application of this project will be in the area of antisense RNA therapeutics.

Filed under

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.