Holistic Approach to the Study of Protein Mechanisms. Start date: April 1, 2004. Expires: March 31, 2009. Expected total amount: $500,000. Principal investigator: Cecilia Clementi. Sponsor: William Marsh Rice University.
Supports the development of coarse-grained models to study the mechanism and dynamics of the protein folding process. Both inverse Monte Carlo and dissipative particle dynamics methods will be used to seek effective potentials, and an algorithm developed for robotics applications will be used for motion-planning on the protein landscape.