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BioInform s Funding Update: NSF Awards in Bioinformatics through June 14, 2003


Bioinformatic Data Mining for AIDS Resistance Genes. Start date: July 1, 2003. Expires: Dec. 31, 2003. Expected total amount: $99,960. Principal investigator: Walter Messier. Sponsor: Evolutionary Genomics.

SBIR Phase I project to develop data-mining software for the identification of genes and genetic mechanisms that contribute to the resistance of primates to the development of full-blown AIDS. It is hoped
that the identified genes and corresponding gene products will lead to development of new therapies for HIV-infected humans.

Algorithms for the Simulation of Short- and Long-Time Dynamics of Proteins. Start date: July 1, 2003. Expires: June 30, 2006. Expected total amount: $405,000. Principal investigator: John Straub. Sponsor: Boston University.

Supports development of computational methods to model protein dynamics on both long and short time scales. Methods will include Monte Carlo simulations, path-integral methods, molecular dynamics, and quantum-chemical methods.

Development and Application of Generalized Ensemble Algorithms for Proteins.
Start date: Sept. 1, 2003. Expires: August 31, 2006. Expected total amount: $328,000. Principal investigator: Ulrich Hansmann. Sponsor: Michigan Technological University.

Supports the development of generalized ensemble algorithms to the study of proteins. New means for computationally enhancing the frequency of transitions between interesting low-energy states will be developed with the goal of increasing simulation efficiency by an order of magnitude. The work will concentrate on understanding how misfolded structures of the b-amyloid peptide form and aggregate.

US-Polish-Czech Workshop on Modeling Interactions in Biomolecules. Start date: June 15, 2003. Expires: May 31, 2004. Expected total amount: $24,960. Principal investigator: Jerzy Leszczynski. Sponsor: Jackson State University.

Workshop to bring together students and researchers from the United States, the Czech Republic, and Poland to discuss current methods of computational chemistry and their application to biological systems.

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The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.