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BioInform s Funding Update: NSF Awards in Bioinformatics through June 14, 2003

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Bioinformatic Data Mining for AIDS Resistance Genes. Start date: July 1, 2003. Expires: Dec. 31, 2003. Expected total amount: $99,960. Principal investigator: Walter Messier. Sponsor: Evolutionary Genomics.

SBIR Phase I project to develop data-mining software for the identification of genes and genetic mechanisms that contribute to the resistance of primates to the development of full-blown AIDS. It is hoped
that the identified genes and corresponding gene products will lead to development of new therapies for HIV-infected humans.


Algorithms for the Simulation of Short- and Long-Time Dynamics of Proteins. Start date: July 1, 2003. Expires: June 30, 2006. Expected total amount: $405,000. Principal investigator: John Straub. Sponsor: Boston University.

Supports development of computational methods to model protein dynamics on both long and short time scales. Methods will include Monte Carlo simulations, path-integral methods, molecular dynamics, and quantum-chemical methods.


Development and Application of Generalized Ensemble Algorithms for Proteins.
Start date: Sept. 1, 2003. Expires: August 31, 2006. Expected total amount: $328,000. Principal investigator: Ulrich Hansmann. Sponsor: Michigan Technological University.

Supports the development of generalized ensemble algorithms to the study of proteins. New means for computationally enhancing the frequency of transitions between interesting low-energy states will be developed with the goal of increasing simulation efficiency by an order of magnitude. The work will concentrate on understanding how misfolded structures of the b-amyloid peptide form and aggregate.


US-Polish-Czech Workshop on Modeling Interactions in Biomolecules. Start date: June 15, 2003. Expires: May 31, 2004. Expected total amount: $24,960. Principal investigator: Jerzy Leszczynski. Sponsor: Jackson State University.

Workshop to bring together students and researchers from the United States, the Czech Republic, and Poland to discuss current methods of computational chemistry and their application to biological systems.

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Others Out There Already

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PNAS Papers on GWAS False Discovery, PRAMEF2 Role in Tumorigenesis, RNA Virus Reverse Genetics

In PNAS this week: strategy to account for GWAS false-discovery rates, role of PRAMEF2 in cancer development, and more.