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Australian Firm Taps Dotmatics Platform to ID Oncology Drug Candidates


Cancer Therapeutics CRC, a small-molecule drug discovery company based in Bundoora, Australia, has selected Dotmatics' informatics platform to provide tools for querying and analyzing data at its research sites.

Cancer Therapeutics CRC focuses on generating lead and preclinical-stage drug candidates. In particular, it looks for potential treatments that target cancer pathways associated with the tumor microenvironment or growth in breast, prostate, melanoma, lung, and brain cancers.

The firm has selected Dotmatics' Browser and Vortex programs to support data sharing and communication with its academic, research, and industrial partners; and to increase its research output.

Last month, Dotmatics announced that Progenra, a Malvern, Penn.-based biotechnology company, had licensed its informatics platform to support drug discovery and development efforts around the ubiquitin-proteasomal pathway of cellular protein regulation (BI 5/25/2012).

Also in May, Basilea Pharmaceutica, a Swiss biopharmaceutical company, licensed the Dotmatics platform to manage its preclinical research data (BI 5/18/2012).

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.