Skip to main content
Premium Trial:

Request an Annual Quote

Astellas to Use Tokyo Tech's Supercomputer to Develop Dengue Antivirals


Astellas Pharma said this week that it has signed an agreement with the Tokyo Institute of Technology that will allow it to use Tokyo Tech's TSUBAME2.0 petaflop-class supercomputer to discover candidates for treating neglected tropical diseases caused by dengue virus.

Astellas said that the partnership will involve two phases. In the first, the researches will mine public information such as patents and published articles to obtain useful knowledge about treatments for diseases caused by dengue virus. In the second phase, they will use in silico screening to identify compounds that are predicted to have anti-dengue virus capabilities.

According to Astellas, Tokyo Tech will be responsible for the data mining and in silico screening calculations of commercially available compounds while Astellas will be in charge of preparing input data for mining, selecting, and listing of hit compounds that will be evaluated.

This is the second research partnership between Astellas and Tokyo Tech. Last summer, they worked on discovering potential candidates for treating NTDs caused by protozoan parasites

Filed under

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.