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Alma Bioinformatica, Applera, Genetic-Xchange, Wellcome Trust Sanger Institute


Alma Bioinformatica of Madrid, Spain, has released JSOTA, a Java-based implementation of the company’s proprietary Self-Organizing Tree Algorithm (SOTA) for expression data analysis.

SOTA is a neural network that grows adopting the topology of a binary tree. The software is available at


Applera’s Applied Biosystems Group, based in Foster City, Calif., has released its Pro ICAT software for the API QSTAR Pulsar Hybrid LC/MS/MS system. According to ABI, the new software automatically identifies and quantifies proteins when used to analyze tandem MS data from ICAT reagent-based proteomics experiments.


Menlo Park, Calif.-based Genetic-Xchange has released the “Oracle Edition” of its K1 Data Integration Middleware Platform. The new edition gives Oracle users a direct connection to over 50 life science data sources and algorithms from within the Oracle environment, according to the company.


Release 7.0 of the Pfam collection of protein domain family alignments is now available from the Wellcome Trust Sanger Institute at

The release contains 3,360 families. Since Pfam 6.0, 320 new families were added and 33 families were deleted.

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The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.